Scanning electron microscopy (SEM) <\/span>images of the compact <\/span>structure of the pericardium.<\/p>\n<\/div><\/div><\/div><\/div><\/div>Thanks to transparency,
\nthe essentials in view<\/p><\/h2><\/div>
biocade\u00ae<\/sup> dura<\/span> is versatile and can be used in a wide range of duraplasties – e.g. when a primary dura closure is not possible.<\/p>\n<\/div><\/div><\/div>biocade\u00ae dura can be adapted to the desired size using standard techniques.<\/b><\/h5><\/div>The short rehydration time makes biocade\u00ae<\/sup> dura convenient and quick to use. biocade\u00ae<\/sup> dura allows repositioning and, since it does not adhere to itself, it can also be transferred through trokars.<\/p>\n<\/div><\/div><\/div>![](\"https:\/\/biotrics.com\/wp-content\/uploads\/2022\/09\/still_7c_brb2.jpg\" "\\"still_7c_brb2\\"")
<\/span><\/div><\/div><\/div>![](\"https:\/\/biotrics.com\/wp-content\/uploads\/2022\/09\/still_9_brb2.jpg\" "\\"still_9_brb2\\"")
<\/span><\/div><\/div><\/div>biocade\u00ae dura allows the surgeon to choose between <\/span>suturing or gluing. <\/span><\/b><\/h5><\/div>After implantation of biocade\u00ae<\/sup> dura, regenerative cells are attracted and their proliferation and migration are promoted by the native collagen. biocade\u00ae<\/sup> dura serves as a scaffold structure that is completely degraded by physiological processes during the formation of a neodura.<\/p>\n<\/div><\/div><\/div>![](\"https:\/\/biotrics.com\/wp-content\/uploads\/2022\/09\/still_12_brb2.jpg\" "\\"still_12_brb2\\"")
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Due to the transparency, the situs can always be monitored and subdural hemorrhages can be detected at an early stage. <\/span><\/b><\/h3><\/div>biocade\u00ae<\/sup> dura is very thin, follows the contours and is therefore very easy to handle. Due to its compacted collagen structure it is waterproof and has a prolonged resorption profile.<\/p>\n<\/div><\/div><\/div>Possible indications for biocade\u00ae dura<\/b><\/h5><\/div>\n- After removal of tumors, cysts or spinal CSF fistulas.<\/li>\n
- Chiari malformations<\/li>\n
- (Rhino)liquorrhea (in onlay, underlay or sandwich technique)<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div>
<\/div>
Hilal Yahya, MD<\/h5><\/div>Specialist in Neurosurgery
<\/h6><\/div>” <\/b>The ideal dura replacement material does not yet exist – <\/span>but biocade\u00ae<\/sup> dura already has a lot of it: <\/span>user-friendly to handle, firm to suture, liquid-tight and transparent – that’s exactly where we want to go.“<\/b><\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>From the product idea <\/span>to the certified product – <\/span><\/h2><\/div>everything from a single source.<\/b><\/h2><\/div>At biotrics, we combine more than 10 years of experience in the development and production of collagen matrices. Our development always follows the needs of the user and is adapted to the clinical requirements. <\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>
![](\"https:\/\/biotrics.com\/wp-content\/uploads\/2022\/09\/biotrics-09492-Bearbeitet-1200.png\" "\\"biotrics-09492-Bearbeitet-1200\\"")
<\/span><\/div><\/div><\/div>Preservation of the outstanding properties of the native pericardium<\/b><\/h2><\/div>The unique manufacturing process intensively purifies and preserves the properties of the porcine pericardium. biocade\u00ae<\/sup> dura thus retains its natural collagen structure and combines considerable tensile strength with an excellent barrier function. The deliberate absence of artificial cross-linking agents or preservatives ensures the proven tissue friendliness of biocade\u00ae<\/sup> dura. <\/span><\/p>\n<\/div>Jung O, Radenkovic M, Stojanovic S, et al. In Vitro and In Vivo Biocompatibility Analysis of a New Transparent Collagen-based Wound Membrane for Tissue Regeneration in Different Clinical Indications. In Vivo. 2020 Sep-Oct;34(5):2287-2295.<\/p>\n<\/div><\/div><\/div><\/div><\/div>
Tensile strength<\/h2><\/div>![](\"https:\/\/biotrics.com\/wp-content\/uploads\/2022\/11\/grafik-zugfestigkeit-dura-en.png\" "\\"grafik-zugfestigkeit-dura-en\\"")
<\/span><\/div><\/div><\/div>The tensile tests show that biocade\u00ae<\/sup> dura provides sufficient tensile strength to withstand physiological loads.<\/p>\n<\/div>Physiological data taken from: Zwirner J, Scholze M, Waddell JN, et al. Mechanical Properties of Human Dura Mater in Tension – An Analysis at an Age Range of 2 to 94 Years. Sci Rep. 2019 Nov 13;9(1):16655.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>
Long resorption profile<\/strong><\/h2><\/div>Histomorphometric examinations of<\/b> up to 90 days <\/span>show the long resorption profile without abnormalities. biocade\u00ae<\/sup> dura degrades slowly and inconspicuously, <\/span>indicating a long barrier effect. <\/span><\/p>\n<\/div>Gueldenpfennig T, Houshmand A, Najman S, et al. The Condensation of Collagen Leads to an Extended Standing Time and a Decreased Pro-inflammatory Tissue Response to a Newly Developed Pericardium-based Barrier Membrane for Guided Bone Regeneration. In Vivo. 2020 May-Jun;34(3):985-1000.<\/p>\n<\/div><\/div><\/div>
![\"\"](\"https:\/\/biotrics.com\/wp-content\/uploads\/2022\/09\/biocade_dura_histoA.jpg\" "\\"biocade_dura_histoA\\"")
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A<\/h6><\/div><\/div><\/div><\/div>
![\"\"](\"https:\/\/biotrics.com\/wp-content\/uploads\/2022\/09\/biocade_dura_histoB.jpg\" "\\"biocade_dura_histoB\\"")
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B<\/h6><\/div><\/div><\/div>![\"\"](\"https:\/\/biotrics.com\/wp-content\/uploads\/2022\/09\/biocade_dura_histoC.jpg\" "\\"biocade_dura_histoC\\"")
<\/div>
C<\/h6><\/div><\/div><\/div>![\"\"](\"https:\/\/biotrics.com\/wp-content\/uploads\/2022\/09\/biocade_dura_histoD.jpg\" "\\"biocade_dura_histoD\\"")
<\/div>
D<\/h6><\/div><\/div><\/div>![\"\"](\"https:\/\/biotrics.com\/wp-content\/uploads\/2022\/09\/biocade_dura_histoE.jpg\" "\\"biocade_dura_histoE\\"")
<\/div>
E<\/h6><\/div><\/div><\/div><\/div>
![\"\"](\"https:\/\/biotrics.com\/wp-content\/uploads\/2022\/09\/biocade_dura_histoF.jpg\" "\\"biocade_dura_histoF\\"")
<\/div>
F<\/h6><\/div><\/div><\/div>![\"\"](\"https:\/\/biotrics.com\/wp-content\/uploads\/2022\/09\/biocade_dura_histoH.jpg\" "\\"biocade_dura_histoH\\"")
<\/div>
G<\/h6><\/div><\/div><\/div>![\"\"](\"https:\/\/biotrics.com\/wp-content\/uploads\/2022\/09\/biocade_dura_histoG.jpg\" "\\"biocade_dura_histoG\\"")
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H<\/h6><\/div><\/div><\/div><\/div><\/div>Pro-inflammatory M1 macrophages or anti-inflammatory M2 macrophages at 10, 30, 60, and 90 days (A, C, E, G, and B, D, F, H, respectively). Abbreviations: CPM – compacted pericardium-based membrane, CT – subcutaneous connective tissue. <\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>
![](\"https:\/\/biotrics.com\/wp-content\/uploads\/2022\/09\/biotrics-09261-Bearbeitet.png\" "\\"biotrics-09261-Bearbeitet\\"")
<\/span><\/div>![\"\"](\"https:\/\/biotrics.com\/wp-content\/uploads\/2022\/09\/Probe1_SeiteA_28177_Mag_-100x_SE_321-mm_HV_-15-kV.jpg\" "\\"Probe1_SeiteA_28177_Mag_-100x_SE_32,1-mm_HV_-15-kV\\"")
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