biocade\u00ae<\/sup> can be safely sewn and even has a significantly higher average thread suture retention strength than the commonly used USP 3\/0* thread material.<\/p>\n<\/div>* Resorbable and synthetic<\/p>\n<\/div><\/div><\/div>
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Due to its compact structure, bio<\/span>cade\u00ae<\/sup><\/span> is characterized by a long resorption profile<\/b>.<\/p>\n<\/div><\/div><\/div>PROPERTIES<\/h3><\/div>\n- native, porcine collagen matrix similar to
\nhuman dermis<\/li>\n - no preservatives or cross-linking agents<\/li>\n
- rapid healing due to early cell migration and revascularization<\/li>\n
- short rehydration term<\/li>\n
- Extremely tear-resistant, yet flexible and malleable<\/li>\n
- easy handling, securely suturable<\/li>\n<\/ul>\n<\/div><\/div><\/div>
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Alba Fricke, MD<\/h5><\/div>Specialist for plastic surgery<\/h6><\/div>“Due to their high biocompatibility and excellent biomechanical properties, I expect collagen matrices such as biocade\u00ae<\/sup> to be a safer, more patient-friendly and tolerable alternative to synthetic meshes.”<\/p>\n<\/div><\/div><\/div><\/div><\/div>Collagen:<\/strong>
\nan essential component of tissues<\/p><\/h1><\/div><\/div><\/div><\/div><\/div>Breast<\/strong> reconstruction<\/h1><\/div>biocade\u00ae<\/sup> is versatile and broadly applicable in various indications – especially when weak subcutaneous fat tissue has to be reinforced during breast reconstruction.<\/p>\n<\/div><\/div><\/div><\/div><\/div>
Excellent integration<\/h4><\/div>After implantation of biocade\u00ae<\/sup>, regenerative cells are attracted and their proliferation and migration is promoted by the native collagen matrix. biocade\u00ae<\/sup> serves as a scaffold structure for the formation of new soft tissue and is completely resorbed.<\/p>\n<\/div><\/div><\/div>![](\"https:\/\/biotrics.com\/wp-content\/uploads\/2022\/11\/grafik-breast.jpg\" "\\"grafik-breast\\"")
<\/span><\/div><\/div><\/div><\/div><\/div>Hernia<\/b> repair<\/h1><\/div>biocade\u00ae<\/sup> is also excellent for hernia repair.<\/p>\n<\/div><\/div><\/div>
“Incisional hernias are one of the
\nmost common postoperative complications”<\/p>\n<\/div>
(Hoer et al. (2002))<\/p>\n<\/div>
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Impressive biomechanical strength<\/span><\/h4><\/div>biocade\u00ae<\/sup> can be used with the standard hernia repair techniques. Since biocade\u00ae<\/sup> does not stick to itself, it is even suitable for laparoscopic placement.<\/p>\n<\/div><\/div><\/div>![](\"https:\/\/biotrics.com\/wp-content\/uploads\/2022\/11\/grafik-laparoskopische-en.jpg\" "\\"grafik-laparoskopische-en\\"")
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From the product idea to the certified product –<\/h2><\/div>everything from a single source.<\/b><\/h2><\/div>At biotrics, we combine more than 10 years of experience in the development and production of collagen matrices. Our development always follows the needs of the user and is adapted to the clinical requirements. <\/p>\n<\/div><\/div><\/div><\/div><\/div>
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Preservation of the outstanding properties of porcine dermis<\/span><\/h1><\/div>Our unique manufacturing process specifically isolates the collagen-containing layers of skin and gently removes all non-collagenous components of the dermis (e.g. foreign proteins, bacteria, viruses, etc.) via a multi-stage purification process. Thus, both the native collagen structure and the very high tensile strength are retained. The deliberate avoidance of artificial crosslinking agents and preservatives ensures the proven tissue friendliness of biocade\u00ae<\/sup>.<\/p>\n<\/div><\/div><\/div>![](\"https:\/\/biotrics.com\/wp-content\/uploads\/2022\/10\/bg-conteiner-04-frei.png\" "\\"bg-conteiner-04-frei\\"")
<\/span><\/div><\/div><\/div>Tensile strength<\/h2><\/div>The tensile tests show that biocade\u00ae<\/sup> provides sufficient tensile strength to withstand the physiological stress.<\/p>\n<\/div>![](\"https:\/\/biotrics.com\/wp-content\/uploads\/2022\/11\/grafik-zugfestigkeit-en.png\" "\\"grafik-zugfestigkeit-en\\"")
<\/span><\/div><\/div><\/div>With 23.4 \u00b1 9.2% elongation at 16 N\/cm, the rehydrated biocade\u00ae<\/sup> meets the established elongation criterion of 10-30% elongation for hernia meshes.<\/p>\n<\/div>Deeken CR, Abdo MS, Frisella MM, et al. Physicomechanical evaluation of absorbable and nonabsorbable barrier composite meshes for laparoscopic ventral hernia repair. Surg Endosc. 2011 May;25(5):1541-52<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>
bio<\/span>cade\u00ae<\/span><\/sup><\/h1><\/div><\/div><\/div>Free from foreign proteins<\/b><\/h3><\/div>Detection of protein purity (SDS-PAGE) of biocade\u00ae<\/sup>.<\/p>\n<\/div>![](\"https:\/\/biotrics.com\/wp-content\/uploads\/2022\/09\/grafik-kollagennase.png\" "\\"grafik-kollagennase\\"")
<\/span><\/div>Sample 1-3: each 3-fold determination of enzymatically digested biocade\u00ae<\/sup>; blank: undigested\/intact biocade\u00ae<\/sup>.<\/p>\n<\/div><\/div><\/div>Biocompatibility and cell migration <\/b><\/h3><\/div>![\"\"](\"https:\/\/biotrics.com\/wp-content\/uploads\/2022\/09\/Seite5-1.jpg\" "\\"Seite5-1\\"")
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Gingiva-fibroblasts seeded on ADM<\/h6><\/div><\/div><\/div>![\"\"](\"https:\/\/biotrics.com\/wp-content\/uploads\/2022\/09\/Seite5-2.jpg\" "\\"Seite5-2\\"")
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Fibroblasts seeded on ADM<\/h6><\/div><\/div><\/div>![\"\"](\"https:\/\/biotrics.com\/wp-content\/uploads\/2022\/09\/Seite5-3.jpg\" "\\"Seite5-3\\"")
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Osteoblasten seeded on ADM<\/h6><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>
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