transparent and pliable

biocade® dura

Transparent collagen matrix
for duraplasty

The high-quality properties of biocade® dura offer neurosurgeons optimal support in their daily challenges. The handling properties of biocade® dura allow easy and wide application in duraplasty, even in confined operating areas. Due to its transparency and biological functionality biocade® dura offers important properties for a predictable treatment outcome.


  • native, transparent collagen matrix for inspection of the subdural situation
  • no preservatives or cross-linking agents
  • supports adhesion and proliferation of regenerative cells
  • long resorption profile provides time for neodura formation
  • CSF-tight and tear-resistant
  • Pliable after a short rehydration for wrinkle-free fixation
  • not self-adherent, low product volume for laparoscopic use
  • very thin (<0.1 mm)

click for large view

Scanning electron microscopy (SEM) images of the compact structure of the pericardium.

Thanks to transparency,
the essentials in view

biocade® dura is versatile and can be used in a wide range of indications – e.g. when a primary dura closure is not possible.

biocade® dura can be adapted to the desired size using standard techniques.

The short rehydration time makes biocade® dura convenient and quick to use. biocade® dura allows repositioning and, since it does not adhere to itself, it can also be used laparoscopically.

biocade® dura allows the surgeon to choose between suturing or gluing.

After implantation of biocade® dura, regenerative cells are attracted and their proliferation and migration are promoted by the native collagen. biocade® dura serves as a scaffold structure that is completely degraded by physiological processes during the formation of a neodura.

Due to the transparency, the situs can always be monitored and subdural hemorrhages can be detected at an early stage.

biocade® dura is very thin, follows the contours and is therefore very easy to handle. Due to its compacted collagen structure it is waterproof and has a prolonged resorption profile.

Possible indications for biocade® dura
  • After removal of tumors, cysts or spinal CSF fistulas.
  • Chiari malformations
  • (Rhino)liquorrhea (in onlay, underlay or sandwich technique)
Hilal Yahya, MD
Specialist in Neurosurgery

The ideal dura replacement material does not yet exist – but biocade® dura already has a lot of it: user-friendly to handle, firm to suture, liquid-tight and transparent – that’s exactly where we want to go.

From the product idea to the certified product –

everything from a single source.

At biotrics, we combine more than 10 years of experience in the development and production of collagen matrices. Our development always follows the needs of the user and is adapted to the clinical requirements.

Preservation of the outstanding properties of the native pericardium

The unique manufacturing process intensively purifies and preserves the properties of the porcine pericardium. biocade® dura thus retains its natural collagen structure and combines considerable tensile strength with an excellent barrier function. The deliberate absence of artificial cross-linking agents or preservatives ensures the proven tissue friendliness of biocade® dura.

Jung O, Radenkovic M, Stojanovic S, et al. In Vitro and In Vivo Biocompatibility Analysis of a New Transparent Collagen-based Wound Membrane for Tissue Regeneration in Different Clinical Indications. In Vivo. 2020 Sep-Oct;34(5):2287-2295.

Tensile strength

The tensile tests show that biocade® dura provides sufficient tensile strength to withstand physiological loads.

Physiological data taken from: Zwirner J, Scholze M, Waddell JN, et al. Mechanical Properties of Human Dura Mater in Tension – An Analysis at an Age Range of 2 to 94 Years. Sci Rep. 2019 Nov 13;9(1):16655.

Long resorption profile

Histomorphometric examinations of up to 90 days show the long resorption profile without abnormalities. biocade® dura degrades slowly and inconspicuously, indicating a long barrier effect.

Gueldenpfennig T, Houshmand A, Najman S, et al. The Condensation of Collagen Leads to an Extended Standing Time and a Decreased Pro-inflammatory Tissue Response to a Newly Developed Pericardium-based Barrier Membrane for Guided Bone Regeneration. In Vivo. 2020 May-Jun;34(3):985-1000.

Pro-inflammatory M1 macrophages or anti-inflammatory M2 macrophages at 10, 30, 60, and 90 days (A, C, E, G, and B, D, F, H, respectively). Abbreviations: CPM – compacted pericardium-based membrane, CT – subcutaneous connective tissue.

Cerebrospinal fluid (CSF) tight

Pressure loading tests show that biocade® dura maintains CSF tightness at physiological intracranial pressures.

The tested stress range of the biocade dura is shown in green. The gray areas compare the expected physiological pressures.

Porcine pericardium

as biomaterial

intensively researched, widely used

Scientific and clinical publications

on porcine pericardial membranes

One Size doesn’t fit all

Art. No. Dimensions Content
750001 1 x 1 cm 1 membrane
750002 2,5 x 2,5 cm 1 membrane
750003 3 x 5 cm 1 membrane
750004 4 x 6 cm 1 membrane
750005 4 x 8 cm 1 membrane